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Manhunter 2: San Francisco is an adventure game created by Barry Murry, Dave Murry, and Dee Dee Murry. It is a sequel to Manhunter: New York, and is again set in a dystopic future where humans have been enslaved by an alien race known as the Orbs. The uprising of the first game did not stop the Orb invasion of Earth, so the player must work with the Orbs while secretly plotting against them to free humanity.

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